Strychnos nux-vomica extract and its ultra-high dilution reduce voluntary ethanol intake in rats.

homeopathy for addictions science

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An integral approach to substance abuse.,Amodia DS, Cano C, Eliason MJ.

integral approach to substance abuse and addictions

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Does additional antimicrobial treatment have a better effect on URTI cough resolution than homeopathic symptomatic therapy alone?

A real-life preliminary observational study in a pediatric population.

Zanasi A1, Cazzato S2, Mazzolini M3, Ierna CM3, Mastroroberto M4, Nardi E4, Morselli-Labate AM4.
Author information
Abstract
BACKGROUND:

The effectiveness of a homeopathic syrup on cough has been demonstrated in an adult population in a previous double-blind randomized study. The present prospective observational study investigated children affected by wet acute cough caused by non-complicated URTIs, comparing those who received the homeopathic syrup versus those treated with the homeopathic syrup plus antibiotic.
OBJECTIVES:

The aims were: 1) to assess whether the addition of antibiotics to a symptomatic treatment had a role in reducing the severity and duration of acute cough in a pediatric population, as well as in improving cough resolution; 2) to verify the safety of the two treatments.
METHODS:

Eighty-five children were enrolled in an open study: 46 children received homeopathic syrup alone for 10 days and 39 children received homeopathic syrup for 10 days plus oral antibiotic treatment (amoxicillin/clavulanate, clarithromycin, and erythromycin) for 7 days. To assess cough severity we used a subjective verbal category-descriptive (VCD) scale.
RESULTS:

Cough VCD score was significantly (P < 0.001) reduced in both groups starting from the second day of treatment (-0.52 ± 0.66 in the homeopathic syrup group and -0.56 ± 0.55 in children receiving homeopathic syrup plus oral antibiotic treatment). No significant differences in cough severity or resolution were found between the two groups of children in any of the 28 days of the study. After the first week (day 8) cough was completely resolved in more than one-half of patients in both groups. Two children (4.3 %) reported adverse effects in the group treated with the homeopathic syrup alone, versus 9 children (23.1 %) in the group treated with the homeopathic syrup plus antibiotics (P = 0.020).
CONCLUSIONS:

Our data confirm that the homeopathic treatment in question has potential benefits for cough in children as well, and highlight the strong safety profile of this treatment. Additional antibiotic prescription was not associated with a greater cough reduction, and presented more adverse events than the homeopathic syrup alone.
KEYWORDS:

Anti-bacterial agents; Antitussive agents; Cough; Homeopathy; Respiratory tract infections

http://www.ncbi.nlm.nih.gov/pubmed/26251722

Evidence in support of gene regulatory hypothesis: Gene expression profiling manifests homeopathy effect as more than placebo

Abstract

Background: Use of ultra-high diluted remedies in homeopathy and their claimed efficacy in curing diseases has been challenged time and again by non-believers despite many evidence-based positive results published in favor of their efficacy in curing/ameliorating disease symptoms. Aims: To test the ability of ultra-high diluted homeopathic remedies beyond Avogadro's limit, if any, in manifesting gene modulating effects in controlled in vitro experimental model. Methods: Since cancer cells manifest aberrant epigenetic gene expressions, we conducted global microarray gene expression profiling of HeLa cells (an established epigenetic model of HPV18 positive cell line) treated with two different potentized homeopathic remedies, namely, Condurango 30c and Hydrastis canadensis 30C (used in the treatment of cancer), as compared to that of placebo (succussed alcohol 30c). Results: Data revealed distinctly different expression patterns of over 100 genes as a consequence of treatment with both homeopathc remedies compared to placebo. Conclusion: Results indicate that action of the potentized drugs was "more than placebo" and these ultra-highly diluted drugs acted primarily through modulation of gene expression.


Evidence in support of gene regulatory hypothesis: Gene expression profiling manifests homeopathy effect as more than placebo (PDF Download Available). Available from: https://www.researchgate.net/publication/279711806_Evidence_in_support_of_gene_regulatory_hypothesis_Gene_expression_profiling_manifests_homeopathy_effect_as_more_than_placebo [accessed Nov 15 2017].

Gene expression profiling manifests homeopathy

effect as more than placebo

Santu Kumar Saha

1

, Sourav Roy

2

and Anisur Rahman Khuda-Bukhsh

1

1

Cytogenetics and Molecular Biology Laboratory, Univ. of Kalyani, West Bengal, India.

2

Depart. Entomology and Inst. Integrative Genome Biology, Univ. of California, USA.

ABSTRACT

Background: Use of ultra-high diluted remedies in homeopathy and their claimed efficacy in

curing diseases has been challenged time and again by non-believers despite many evidence-

based positive results published in favor of their efficacy in curing/ameliorating disease

symptoms. Aims: To test the ability of ultra-high diluted homeopathic remedies beyond

Avogadro?s limit, if any, in manifesting gene modulating effects in controlled in vitro

experimental model. Methods: Since cancer cells manifest aberrant epigenetic gene expressions,

we conducted global microarray gene expression profiling of HeLa cells (an established epigenetic

model of HPV18 positive cell line) treated with two different potentized homeopathic remedies,

namely, Condurango 30c and Hydrastis canadensis 30C (used in the treatment of cancer), as

compared to that of placebo (succussed alcohol 30c). Results: Data revealed distinctly different

expression patterns of over 100 genes as a consequence of treatment with both homeopathc

remedies compared to placebo. Conclusion: Results indicate that action of the potentized drugs

was ?more than placebo? and these ultra-highly diluted drugs acted primarily through

modulation of gene expression.

Key words: Gene regulatory hypothesis, DNA microarray profile, potentized remedies.

Introduction

Homeopathy is one of the most widely practiced controversial modes of treatment as it uses extremely diluted

remedies in micro-doses to alleviate patients? complaints. Despite being used for centuries with great effect,

non-believers of homeopathy mainly ask two questions: (a) as drugs diluted beyond Avogadro?s limit (6.023 x

10

23

) are not expected to contain even one single molecule of the original drug substance, how can the

homeopathic medicines then be physical-chemically different from ?vehicle? ethanol, and claimed to be

effective in curing many diseases? (b) What might the mechanism of action of these ultra-highly diluted

remedies be?

In this report, we present gene expression profiling results that give strong support to a hypothesis proposed

by Khuda-Bukhsh [1, 2], to wit, that potentized homeopathic drugs act through regulation of gene expression.

Thangapazham et al. [3], in turn, apparently failed to find changes in gene expression induced by

homeopathic drugs used in in vitro experiments with human breast cancer cells MDA-MB-231, human

prostate cancer cells DU-145 and LNCaP, and rat prostate cancer cells MAT-LyLu treated with some

potentized homeopathic remedies like Conium maculatum, Sabal serrulata, Thuja occidentalis, Asterias

rubens, and Phytolacca decandra in dilutions 30c, 200c and 1,000c, and Carcinosinum (1,000 c) although they

Int J High Dilution Res 2013; 12(45):162-167

163

had found in an earlier in vivo study reduction in the number and size of cancer nodules supported by

histological analysis in prostate cancer MAT-LyLu cell?injected Copenhagen rats given homeopathic

treatment containing Thuj, Con, Sabal serrulata, and in MAT-LyLu cell with Carc [4]. However, the authors

did not conduct gene expression studies of any signal proteins in these rats in vivo, where modulation of

certain gene expression would be expected.

The controversy surrounding research in homeopathy moves along two different directions. On the one hand,

the mechanism of action of the potentized homeopathic remedies diluted beyond Avogadro's limit remains an

open research problem, which has received widespread attention from the research community, and many

competing hypotheses have been proposed. On the other hand, some studies that indicate homeopathy is no

better than placebo, which thus makes any claim about the mechanism of action of homeopathic drugs null

and void. There have been many results highly critical of homeopathy. For example, The Lancet of August 27,

2005 featured an article that was highly dismissive of homeopathy [5] along with a press release:

?homeopathy is no better than placebo?. The meta-analysis was accompanied by a short, anonymous editorial

entitled ?The end of homoeopathy?. This resulted in the eruption of a ravaging controversy: whether

homeopathy is really better than placebo or not, culminating in a debate in the British Parliament

[6].

Homeopathy was decried and its use as a beneficial and scientifically proven mode of treatment was voted

against. However, most clinical research conducted with homeopathic medicines has shown positive results

[7]. Biological activities of ultra-high diluted potentized homeopathic remedies have also been confirmed by

basic research studies with respect to a multitude of scientifically accepted protocols, both in animals and

plants in vivo and in vitro

[8]. Nevertheless, the argument persisted, as ultra-highly diluted homeopathic

medicines are supposed to possess "nothing" in terms of the original drug molecules, and as such their effect

on biological systems was unacceptable until recently. During the last few years, presence of ?nanoparticles?

of the starting materials, even at extremely high dilutions, has been reported [9, 10]. Moreover, Montagnier

[11] countered through experiments that ?high dilutions of something are not ?nothing?, they are water

structures which mimic the original molecules".

We decided to use one of the most modern tools, global microarray profiling of genes, to verify whether the

effects of ultra-highly diluted homeopathic drugs on the expression profile of genes were distinctly different

compared to ?placebo?. DNA microarrays are widely used to measure the expression levels of large numbers of

genes simultaneously, with the aid of selective probes under highly stringent conditions. Gene expression

profiling experiments are specially effective for monitoring the expression levels of thousands of genes to

study the effects of certain treatments, for example, to identify genes whose expression changes in response to

pathogens or drugs, by comparing the gene expression in the infected and drug-treated cells or tissues [12].

Materials and methods

The aim of the present study was, therefore, to find out whether the global gene expression profiles in cancer

cell line, HeLa (an established epigenetic model of HPV18 positive cell line) differed significantly, in

quantitative as well as qualitative terms, after treatment with 2 homeopathic remedies used against cancer

[13-15], namely, Condurango 30c and Hydrastis canadensis 30c (both diluted 10

-60

times, much above

Avogadro?s limit) compared to ethanol 30c, (placebo, prepared from the same stock of 70% alcohol giving 10

jerks at each step in the same manner as the verum was potentized). Affymetrix Gene Chip Human

Primeview gene expression arrays were used for this purpose.

Cervical cancer cell line HeLa was obtained at National Centre for Cell Science, Pune. The cells were

routinely maintained in Dulbecco?s Modified Eagle?s Medium supplemented with 10% FBS and 1% antibiotic

at 37 ?C in a humidified incubator containing 5% CO

2

. The cells were plated one day before treatment. 4%

(v/v) of drugs and ?placebo? (succussed ethanol 30c, 10 jerks at each step of dilution) were added to the cell

Int J High Dilution Res 2013; 12(45):162-167

164

cultures and kept for 48 hr. Cells without any treatment in the normal medium were considered as negative

control.

Separate groups of cells were subjected to treatment with Cond 30c, Hydr 30c, and succussed alcohol placebo.

The cells were sent to iLife Discoveries, Gurgaon, India for providing us global microarray data conducted on

Affymetrix platform, using 25-mer probes. The total number of probes detected for the experiment was

49,395; hybridization was performed at 45

o

C for 16 hrs at 60 rpm.

Slides were scanned with 3000 7G microarray scanner and raw data sets were extracted from the Cel (raw

intensity) files. Microarray data analysis, differential gene expression analysis, fold change analysis and

cluster analysis were performed using GeneSpring GX12.5 software.

Results and discussion

Microarray data analyses showed that out of a total of 40,678 genes, for which probe sets remained after data

processing, normalization and quality control, 6,024 were differentially expressed at a p-value cutoff of 0.05,

in a one-way ANOVA. The expression levels of the genes in the cells were treated with Hydr 30c (Set I) and

Cond 30c (Set II) were compared to the levels in the untreated (control) as well as succussed ethanol 30c

(placebo) treated cells (Set III). Using a cutoff of 1.5 folds it was observed that in Set I, 3 genes each were up-

and down-regulated when compared to the control as well as Set III samples. Similarly, there were 2 genes in

Set II that were up-regulated by at least 1.5 folds when compared to the two sets mentioned above, whereas

122 genes were down-regulated by ?1.5 folds. Two and 10 genes were up- and down-regulated by ? 1.5 folds,

respectively, in both sets (Set I and Set II) when compared to the control as well as Set III. In addition, there

were another 23 genes in Set I and 12 genes in Set II that were differentially expressed by ? 1.5 folds, when

compared to Set III. Upon comparing the expression levels of genes in Set I and Set II, it was observed that

for 36 genes, there were ? 1.5 fold differences in expression between the 2 treatments. These findings suggest

that the drugs did not only affect the gene expression, but also that the effect of one drug was different from

the other in a number of genes.

The findings of the present study clearly demonstrate that the expression profiles of certain genes of the drug-

treated HeLa cells were significantly different from that of the placebo treated cells. This suggests that both

drugs and placebo differed in their ability to trigger gene responses, some of which were implicated in cancer.

Thus, although the drugs were ultra highly diluted, they still retained the ability to trigger gene responses in

a cascade of reactions, diving support to Khuda-Bukhsh?s hypothesis[1-2]. Epigenetic modifications are a

hallmark of cancer, and a large number of genes remain in modified state of expression in cancer cells. Both

Hydr [13, 15] and Cond

[14, 15] had been previously reported to induce apoptosis in cancer cells, while

?placebos? do not exhibit this property. Therefore, it is logical to infer that homeopathic remedies contain

some form of molecular imprints of the original drug substance [16], while the ?placebo?, in the absence of

such imprints, fails to elicit the required effect.

Incidentally, ultra-highly diluted preparations of glucose 30c, Arsenicum album 30c, and Arnica montana 30c

were shown to induce gene modulatory effects in bacteria, E. coli and yeast Saccraromyces cerevisiae, either

subjected to insult with sodium arsenite or UV-irradiation [17-19]. Those authors [17-19] explained that the

potentized homeopathic remedies carry specific "signals"/"information" that can be identified by certain cell

receptors. Those "signals" may act as a "trigger" for turning "on" or "off" some relevant genes, initiating a

cascade of gene actions, while the ?placebo? failed to elicit any such favorable responses. It has been

previously documented that administration of a potentized homeopathic drug altered the expressions of a

large number of signal proteins in mice induced to develop skin cancer

[20].

Int J High Dilution Res 2013; 12(45):162-167

165

The results of the present study, therefore, contribute to support the gene regulatory hypothesis proposed by

Khuda-Bukhsh [1, 2]. Further studies are needed to ascertain the ability of Cond 30c, if any, to modulate

activities like DNA methylation/demethylation and histone acetylation/deacetylation, 2 hallmarks of

epigenetic modifications, to produce additional support to the gene regulatory hypothesis.

Author contributions

ARK-B conceptualized and designed the experiments, SS performed the experiments, SR analyzed and

interpreted the microarray data, ARK-B and SR wrote the manuscript.

References

[1] Khuda-Bukhsh AR. Potentized homeopathic drugs act through regulation of gene expression: a hypothesis

to explain their mechanism and pathways of action in vivo. Comp Ther Med 1997; 5: 43-46.

[2] Khuda-Bukhsh AR. Towards understanding molecular mechanisms of action of homeopathic drugs: an

overview. Mol Cell Biochem 2003;253: 339-45.

[3] Thangapazham RL, Gaddipati JP, Rajeshkumar NV, et al. Homeopathic medicines do not alter growth and

gene expression in prostate and breast cancer cells in vitro. Integr Cancer Ther 2006; 5:356-61.

[4] Jonas WB, Gaddipati JP, Rajeshkumar NV, et al. In vitro and in vivo assessment of homeopathic

treatment for prostate cancer. Paper presented at: Society of Integrative Oncology First International

Conference; November 18, 2004; New York, NY.

[5] Shang A, Huwiler-M?ntener K, Nartey L, et al. Are the clinical effects of homoeopathy placebo effects?

Comparative study of placebo-controlled trials of homoeopathy and allopathy. Lancet 2005; 366:726-32.

[6] U.K. Parliamentary Committee on Science and Technology: Evidence 2. 2010, available at

http://www.publications.parliament.uk/pa/cm200910/cmselect/cmsctech/45/4502.htm.

[7] Clausen J, van Wijk R, Albrecht H. Review of the use of high potencies in basic research on

homeopathy.Homeopathy 2011; 100:288-92.

[8] The HomBRex database 2012.http://www.carstens-stiftung.de/hombrex/index.php.

[9] Chikramane PS, Suresh AK, Bellare JR, et al. Extreme homeopathic dilutions retain starting materials: A

nanoparticulate perspective. Homeopathy 2010; 99: 231-42.

[10] Bhattacharyya SS, Mandal SK, Biswas R, et al.In vitro studies demonstrate anticancer activity of an

alkaloid of the plant Gelsemium sempervirens.Exp Biol Med (Maywood) 2008; 233:1591-601.

[11] Montagnier L. Newsmaker interview: Luc Montagnier. French Nobelist escapes 'intellectual terror' to

pursue radical ideas in China. Interview by Martin Enserink.Science 2010; 330:1732.

[12] Adomas A, Heller G, Olson A, et al. Comparative analysis of transcript abundance in Pinus sylvestris

after challenge with a saprotrophic, pathogenic or mutualistic fungus". Tree Physiol 2008;28: 885?897.

[13] Saha SK, Sikdar S, Mukherjee A, et al. Ethanolic extract of Goldenseal, Hydrastis canadensis has

demonstrable chemopreventive effects on HeLa cells in vitro: Drug-DNA interaction with calf thymus DNA as

target. Environ Toxicol Pharmacol 2013; 36: 202-214.

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[14] Mitsuhashi H et al. Condurango glycoside compounds processes for their preparation, antitumor agents

comprising them and compositions. United States Patent 1984.

[15] Boericke W. Pocket manual of homeopathic material medica & repertory. reprint edn 2004. B. Jain

Publishers (P) Ltd, India. 2002: 514.

[16] Davenas E, Beauvais F, Amara J, et al.Human basophil degranulation triggered by very dilute antiserum

against IgE.Nature1988; 333:816-8.

[17] Saha SK, Das S, Khuda-Bukhsh AR.Phenotypic evidence of ultra-highly diluted homeopathic remedies

acting at gene expression level: a novel probe on experimental phage infectivity in bacteria. Zhong Xi Yi Jie

He Xue Bao 2012; 10:462-70.

[18] Das S, Saha SK, De A, et al. Potential of the homeopathic remedy, Arnica Montana 30C, to reduce DNA

damage in Escherichia coli exposed to ultraviolet irradiation through up-regulation of nucleotide excision

repair genes.Zhong Xi Yi Jie He Xue Bao 2012;10:337-46.

[19] Das D, De A, Dutta S, et al.Potentized homeopathic drug Arsenicum Album 30C positively modulates

protein biomarkers and gene expressions in Saccharomyces cerevisae exposed to arsenate.Zhong Xi Yi Jie He

Xue Bao 2011;9:752-60.

[20] Khuda-Bukhsh AR, Bhattacharyya SS, Paul S, et al. Modulation of Signal Proteins: A Plausible

Mechanism to Explain How a Potentized Drug SecaleCor 30C Diluted beyond Avogadro's Limit Combats Skin

Papilloma in Mice. Evid Based Complement Alternat Med 2011;2011:286320.


Evidence in support of gene regulatory hypothesis: Gene expression profiling manifests homeopathy effect as more than placebo (PDF Download Available). Available from: https://www.researchgate.net/publication/279711806_Evidence_in_support_of_gene_regulatory_hypothesis_Gene_expression_profiling_manifests_homeopathy_effect_as_more_than_placebo [accessed Nov 15 2017].https://www.researchgate.net/publication/279711806_Evidence_in_support_of_gene_regulatory_hypothesis_Gene_expression_profiling_manifests_homeopathy_effect_as_more_than_placebo

Just One Drop - the story behind the homeopathy controversy by Health Action Network Society (HANS)

Just One Drop - In Vancouver, October 17th, 2017

by Health Action Network Society (HANS)

Description

Part of the Health Action Film Series, JUST ONE DROP tells the little known story of homeopathy: the most controversial system of medicine. To many, homeopathy seems implausible. They fear it is purely a placebo effect or worse, a form of deception or quackery. Yet, homeopathy has been around for over 200 years and is used by millions of people around the world. The film explores the controversy, reveals the rich history, dispels myths and misconceptions, and asks whether or not homeopathy been given a fair shake.

Panel discussion to follow screening.

The Just One Drop trailer may be viewed here.

https://www.eventbrite.ca/e/just-one-drop-the-story-behind-the-homeopathy-controversy-tickets-37436307002

 

 

Homeopathic Medicine Controversial Medicine

An Alternative Approach in The Treatment of Methicillin-Resistant Staphylococcus Aureus (MRSA), using Classical Homeopathy by Pierre Fontaine RSHom CCH.

Introduction

MRSA (Methicillin-resistant Staphylococcus aureus) is a bacteria that is resistant to most common antibiotics. Aside from methicillin the bacteria is also resistant to other more common antibiotics such as oxacillin, penicillin and amoxicillin. 1 Staph infections, including MRSA, occur most frequently in patients who have recently been hospitalised for long periods, who have had invasive medical procedures or who have weakened immune systems. Individuals treated in long term healthcare facilities such as nursing homes or dialysis centres have been considered most at risk. In a healthcare setting can cause serious and potentially life threatening infections such as bloodstream infection, infections at a surgical site, or pneumonia. However, MRSA infections also occur in otherwise healthy people who have not recently been hospitalised or undergone an invasive medical procedure. These infections usually present as skin infections, pimples, boils or other pus-filled lesions but can rapidly progress to more life threatening infections. In this otherwise healthy population they are known as community associated (CA)-MRSA infection; according to a recent study2 MRSA has become the most frequent cause of skin

1 Centres for Disease Control. Overview of healthcare related MRSA

2 Invasive Methicillin-Resistant Staphyloccus aureus infections in the United States. R. Monina Klevens, DDS, MPH et al. www.jama.com at CDC-Information Center.

and soft tissue infections presenting at emergency rooms in the USA. During the period from 1999 to 2005 the estimated number of hospitalizations involving S.aureus-related infections increased 62% from 294,570 to 477,927. In 2005, there were 11,406 S. aureus– related deaths of which 6,639 were MRSA-related3.

Current medical treatment for MRSA usually involves removing the infected person to an isolation ward and the use of the intravenous antibiotic vancomycin. The hospital stay can be several days. The patient is usually sent home with wound care instructions and a prescription for the ointment bactroban which is applied to the internal nasal passages. The infection can be controlled this way, but in many cases the patient will remain colonised. While vancomycin is currently effective against MRSA it is clear that increased resistance exists and some hospitals are already reporting strains that are less sensitive to vancomycin. 4

Homeopathy

In this light, it seems important to examine the potential of alternative therapies that do not make use of costly drugs or hospital stays, to combat such infections and prevent the risk of developing further antibiotic resistant bacterial strains. Homeopathy is widely practiced throughout Europe and Asia and is increasing in use in the US. In the UK the NHS (National Health Service) operates 5 dedicated homeopathic hospitals. According to a 2005 study, 70% of 6544 follow-up patients reported improvements in their health. Among the ailments most commonly treated were eczema, asthma, migraine, irritable bowel syndrome and

3 Klein E, Smith DL, Laxminarayan R.

Hospitalizations and deaths caused by methicillin-

resistant Staphylococcus aureus, United States,

1999–2005. Emerg Infect Dis [serial on the Internet].

2007 Dec [25 Sept 08]. Available from

http://www.cdc.gov/EID/content/13/12/1840.htm

4

http://www.mayoclinic.com/health/mrsa/DS00735/DSECTION=tr eatments-and-drugs

1

chronic fatigue.5 In the modern day context there is unfortunately little data on the use of homeopathy in acute outbreaks of infectious disease but historically it has been effectively applied in outbreaks of cholera, influenza and scarlet fever. During the 1918 Spanish Influenza epidemic data collected by the Hahnemann College of Medicine in Philadelphia showed a mortality rate of only 1.05% amongst a group of 26,795 cases treated by homeopaths. The mortality rate in the general population treated medically was 30%.6

Homeopathy is symptom driven and based on careful observation of the individual signs and symptoms as exhibited by the patient. It is experiential and the homeopath pays extremely close attention to the use of language by the patient in relating how the ailment is affecting him. A remedy acts as a reversing trigger on the self-healing vital force of the body that is being challenged. It is described as working at a vitalistic level, similar to acupuncture. It is bio- dynamic in nature rather than bio-chemical, as western medicine is.

Homeopathy is very effective in chronic illnesses but as the case below illustrates, homeopathy can also be extremely effective in acute infections that require daily monitoring and frequent re-evaluation of remedy selection.

Case Presentation History

James, an otherwise healthy 40 year old man entered our care in late November 2007. He had sustained a minor scratch on his finger at the end of September 2007 while clearing away vegetation in upstate New York. Despite thorough wound care at the time James’ finger

5 Spence DS, Thompson EA, Barron SJ. Homeopathic treatment for chronic disease: a 6-year university-hospital outpatient observational study. Journal of Alternative & Complementary Medicine 2005; 11: 793-798. http://www.trusthomeopathy.org/csArticles/articles/000001/000 164.htm

6 Homeopathy for Epidemics. Eileen Nauman, DHM (UK). Pg 11

began swelling up during the night of the scratch and within 3 days had progressed to a severe infection. James sought advice at a walk in clinic near his home and was prescribed antibiotics. He had no improvement over the next two days at which point he visited the Emergency Room at Columbia Presbyterian hospital in New York City. His finger was red, edematous and showed clear signs of infection. His wound was lanced in the ER and the exudates sent for analysis. As a precaution James was admitted to the hospital overnight and received an IV antibiotic and analgesics. On discharge the next day he was instructed about wound care and hoped the infection would clear. However, he received a message 2 days later informing him that the culture grown from his lab specimen was not responding to antibiotics and was confirmed as being MRSA.

James was immediately readmitted to the hospital, this time in an isolation ward to avoid exposure to any other patients. Vancomycin was prescribed and he was sent home with bactroban ointment for his nose 2 days later. He was advised that the infection could re- occur and to be vigilant about skin lesions.

Two months later, just after Thanksgiving, James noticed a large, fleshy bulge on the back of his thigh. He was concerned it might be a recurrent MRSA skin infection but as an uninsured patient was forced to seek an alternative to another costly hospitalisation. On the recommendation of a friend he sought homeopathic treatment.

Homeopathic findings

When I first spoke with James he described how the wound on his middle finger in September “blew up” within a day to a hard swelling. His fever spiked to 102F. Now, two months later, the presenting symptom was a large swelling on the back of his right thigh just below his buttock. He described how it “came right out” close to 1 inch in thickness and then

2

reverted to a very large “bite-like,” dark dot within a day. Light red discolouration of the skin was seen almost down to his knee. The lump was sharply7 painful and causing him concern. It was constricting his leg and felt very hard. He felt as if an iron band was preventing movement. He was concerned because he thought it might be the same, incurable infection as the first one on his finger.

Based on the sensation of constriction that he repeated in many different ways and the other symptoms listed in italics I prescribed Cactus Grandiflora. I also stressed the importance of being seen by a medical doctor. James however steadfastly refused to return to the hospital.

At this stage about five dozen remedies were identified as being valid homeopathic remedies for this individual. Careful differentiation and research would clarify final remedy selection, according to homeopathic repertories and Materia Medicas.

24 hours later (from initial consultation)

After one day the sensation of constriction was significantly diminished. The pain had lessened but the infection was not improving. The central area of induration was growing

7 Italicized words in this description of finding represent qualities specifically used in selecting the proper homeopathic rememdy.

larger but he described marked improvement in the sensation of his most prevalent symptom, i.e. the swelling and the constricting. The discolouration that had spread to his knee was more localised. At this stage I repeated the same remedy.

2 days later

Though the infection seemed contained the central area now resembled a large boil and had grown rapidly to a darker red circle of about 4 inches. At this point he complained of severe “burning pains”, and the infection was described (and looked) as ‘angry’. He was also extremely restless with a constant need for motion. At this point I had several remedies in mind that might have fit the symptom picture, but the degree of anger and burning in the case led me to Cantharis.

3

3 days later

James reported that the Cantharis had addressed the burning pains which now felt much better. He was happy that he did not have to take pain medication as he had with the first infection. The outward progression of the infection had clearly stopped and the boil turned even darker red with a congested, shiny appearance and blood seeping through the pores in the centre of the mass. According to these symptoms, Crotalus Horridus was given, as it is often used for dark, haemorrhagic wounds. I had previously researched this remedy in regards to Ebola type infections several years ago.

All along James was repeatedly advised to seek medical care and have the wound lanced. There was concerned about a systemic blood infection. James pointed out that he had no fever at all and that the swelling had stopped.

His pain was manageable and was not requiring the high doses of narcotics he had needed during his first MRSA infection. He was confident that the lesion was healing and could not afford the high cost of another hospitalisation so he was not willing to seek medical attention.

During this time James did stay in his apartment to avoid any possibility of secondary infection.

4 days later

24 hours after the Crotalus the boil began changing colour. Yellow and light green pus could be seen in the border. His pain was manageable and he had no fever.

At this point James described intense anxiety over the possibility of MRSA occurring over and over and over again in his life. He felt he was poisoned for life. The increased anxiety along with the idea that his body was poisoned and that he had an incurable disease indicated the remedy Arsenicum Album.

6 days later

Clearly the infection was no longer spreading. James’ anxiety was much diminished. The boil was filled with pus and began oozing but there was no way to know what was going on underneath the mass of pus and necrotic tissue. He felt very good about his

4

progress but I remained concerned about systemic infection and necrosis at the infection site. Secale was given as a prophylactic for blood poisoning. Within half a day his anxieties and restlessness came back. It was clear this remedy was not having an effect and I reverted to Arsenicum.

Continuing Progress

On the 7th day the mass opened and began oozing. At this point James was able to manually squeeze the lesion and exude a large amount of dark green, almost black pus. At this stage James collected several of the cotton balls he had used to drain the exudate and on the 6th December 2007 he had them analysed at the same laboratory facility as his earlier sample. The exudate was confirmed as positive for MRSA.

Later on the wound stopped seeping and began to dry up. I continued to prescribe Arsenicum daily and James remained vigilant about cleaning the wound with hydrogen peroxide. I was encouraged that at the time the lesion burst there was already evidence of granulation on the borders. This was evidence to me that the infection had been fully isolated.

Over the next two weeks the wound continued to slowly heal from the outside edges towards the centre and from the bottom of the ulcer to the surface of the skin. Within 3 weeks

the lesion had healed over completely. James continued to take Arsenicum several times a day as he still had some level of anxiety regarding re-infection. We were gradually able to reduce the frequency of repetition as the wound continued to heal and his anxiety diminished.

5 months later

James continues to do well and on the 9th of April 2008 he returned to Columbia for another nasal swab analysis. Remarkably the tests came back negative for MRSA, meaning that not only was his local infection cured but his body was no longer colonised by the bacteria. In other words, his wound was completely healed and he is no longer a carrier of MRSA in the general population.

5

Conclusion

Given the growing number of antibiotic resistant infectious agents, a treatment for MRSA that avoids all use of antibiotics has enormous potential in the general population. Furthermore, the treatment above is reproducible in a hospital setting using the basic five dozen remedies that fit the MRSA symptom picture. There is also the possibility of using other homeopathic remedies prophylacticaly. To that end we recommend and hope to undertake further research on this approach in a traditional medical facility.

http://homeopathicservices.com/resources/explore-nov-dec-2009/

Dr. Iris Bell M.D. Ph.D. does it again!

Research in Homeopathy:

If anyone is ever asking you to back up your interest in homeopathy with 'Evidence-based Research' or 'clinical proof' or RCT (Random Control Trials) scientific research, please help them by referring to this list or also by sharing this email. Here is a link that displays a pdf of a Reference List of 138 pages worth of Homeopathic Research. This list was curated by Dr. Iris Bell M.D. Ph. D. and Peter Gold in 2015. Much more research has been published since this collection almost two years ago. Hope this helps lead anyone to any type of research with regards to the use of homeopathy and homeopathic remedies. Anyone is welcome to download this pdf file and use it or pass it on. http://www.homeopathy.ca/pdf/HomeopathyResearchEvidenceBase_10-29-15.pdf

Homeopathic Remedies for your Hot Summer Holidays

Emergency Remedies to bring to your beach days:

For sensitive skin:

Calendula can be used internally as a homeopathic remedy for sunburns that do not blister but feel hot, burning and itches. Urtica is another commonly used homeopathic remedy that can be taken internally for a typical sunburn with no blisters but itching and burning.

Cantharis is an excellent homeopathic remedy for burns that blister or are about to blister. For any serious burn, cantharis is a potent healing to relieve the pain and promote the healing of second degree burns.

For sunstroke or heat exhaustion; If you've gotten more direct sun than your body could handle at a time you may have headaches, dizziness, weakness, nausea, fever, flushed skin, dry skin and even confusion or fainting. You would definitely need to re-hydrate as much and as soon as possible. Belladonna is a powerful homeopathic remedy that can restore your strength. Belladonna can act fast if it is the correctly indicated remedy. Glonione is another potent homeopathic remedy to have on hand in case of sunstroke. Cuprum metallicum if there is some cramping of your muscles that develops along with the sunstroke.

Travelling with your Homeopathic Remedies to protect homeopathic ingredients from X-Rrays


When traveling with homeopathic remedies, pass the remedies to the guard for manual screening and do not put them through the security x-ray scanners. Depending on where you will be travelling to/from - you could find out the EMR (electro-magnetic ray) strength used at each of the luggage and security line ups for each airport you will be travelling to. That way, you can decide which remedies you would like to carry with you or which ones you would like toput in your luggage. The lead bags that film is stored in for airport x-ray prevention may also be of use.

Children's Cough remedies

Coughs

A cough is a body’s way of clearing the delicate air passages of irritants, most usually mucous. The mucous has been produced as a sticky substance to carry viruses, bacteria, inhaled particles (i.e. dust, pollen) and dead white blood cells out of the body. It is best to not use cough medicines because they interfere with the natural protective mechanism of the lungs to rid themselves of mucous. If repressed, a cough can lead to deeper infections. Or it will take longer for the child to get rid of the cough completely. Utilizing homeopathy aids the body in ridding itself of the cough and making the child more comfortable. Coughs can be hard to deal with because of a large variety of symptoms. There are many things to take into account. Be patient! Try not to get discouraged; you may need to evaluate the case two or three times. You may need to repeat a remedy a few times a day over the course of a few days. A neglected persistent cough can lead to or indicate other problems, so it is advisable to get an evaluation by your health care practitioner, if the cough is not resolving.

   The American Academy of Pediatrics states that over-the-counter cough and cold medicines should not be given to children under the age of 6 years old, because they do not work and can have dangerous side effects. There are warning labels on these products which state that they should not be given to children under the age of 2 years old.


A chest infection can lead to various other more serious conditions. Fever is associated with all of these at some point. (Look to fever section below for further indications and verification of the right remedy). A course of antibiotics is the preferred orthodox treatment. Even if the condition is viral, doctors want to prevent opportunistic bacteria from colonising in the already compromised lungs. The viruses and bacteria take hold of the body because of susceptibility due to being run down, highly stressed out, being severely depressed or deeply grieved, being out of balance or sleep deprived. Chest infections can quickly spin off into serious conditions in those who are hereditarily susceptible, weak (especially an infant), a teen who smokes, or being on some long term medications. It is most significant how the body signals its distress by producing an individual set of symptoms. The diagnosis “Chest infection” is generally applied to a cough with mucus in the lungs and is usually the result of not taking care in the initial stages of a common cold. It is really important to read “CALL YOUR HEALTH CARE PRACTITIONER IF” section below so you know when to seek help if there is a serious turn of events in chest complaints.

A little anatomy lesson here so you can tell where the cough is originating: 

Pharynx The back of the tongue where it turns and goes into the throat.

LarynxThe throat down to the throat pit, just below the Adam’s apple, that is called the voice box.

TracheaThe wind pipe just before the lungs.

BronchusThe main tube into the lungs.

BronchiolesThe smaller tubes on both sides that carry the air in and out of the lungs.

Croup – Croup is an inflammation of the larynx, trachea and sometimes into the bronchus. Because of swollen mucous membranes, the air passages become narrow. This gives the cough the “croupy, metallic, barking” sound. (Think of a high-pitched and hoarse dog barking or a barking seal). The cough is sometimes described as the sound of a barking seal. It is usually brought on by a cold or influenza in children 6 months to 4 years old. It usually starts with hoarseness. Croup may or may not be accompanied by fever.  It often starts suddenly around midnight. Child usually wakes in a panic because they are having trouble breathing. Then they begin coughing. If the cough is severe, they may gag or choke. It is usually much worse at night and less severe during the day. Croup requires careful watching in the very young because the symptoms can change rapidly. To ensure that the airways are kept open, prop the child up with a pillow. Make sure that fluid intake is kept high. You may warmly wrap the child (i.e. hat, mittens, socks, completely covered in warmth) and take them into the cool night air for about five minutes. This reduces swelling in the airways.  Do not take them out if it is bitter cold, as this can shock the lungs. A cool mist vaporizer in the child’s room can also be helpful. If the child has been coughing and gagging for more than 24 hours despite initial treatment, call your health care practitioner. A child, who has croup several times or does not get rid of the cough in between bouts, needs to be evaluated by your health care practitioner. Occasionally a child will not respond to indicated remedies and the symptoms of croup become so alarming that hospital becomes the only course to take. If there are no results, call your health care practitioner. See #13 in the “Call Your Healthcare Practitioner If” section and inform yourself about epiglottis.

As stated above, croup often starts suddenly around midnight. This indicates Aconitum as an initial remedy, but there are other symptoms that point to it as well: heat; anxiety; restlessness; hoarseness; cough is dry and barking (like a seal); short difficult breathing. One dose (2 pellets) will often ease the symptoms immediately. If symptoms persist repeat in ½ hour. If there are no results, and the child’s breathing sounds harsh, is becoming more laboured, and the cough is persisting, give a dose of Spongia Tosta. Wait another ½ hour. If your child is not asleep by now, and the breathing is still not easy with continued coughing, give a dose of Hepar Sulph.  However, usually after 2 doses of Aconitum, the child is better.

The main remedies for croup are Aconitum, Hepar Sulph., and Spongia Tosta. There are a few others as well.  (see below in the Cough section). If there are no results from the above remedies, look to other remedies: Arsenicum, Belladonna, Iodium, Ipecacuanha, Kali Bich, Lachesis, Phosphorus, Rumex (see below).

Whooping Cough This information is here because there have been many cases where the child has been immunized with the DPT vaccine, yet still developed whooping cough. (The “P” in DPT stands for Pertussis). Whooping cough is cause by the Bordetella
pertussis
bacteria. It is sometimes referred to as pertussis. The ‘whoop’ sound is a hoarse intake of a breath at the end of a bout of coughing. The bacteria emit toxins which paralyze the cilia in the lungs. The cilia are like tiny hairs that line the respiratory openings. Because of the paralysis, inflammation sets in, which interferes with the clearing of normal mucous. Thick, sticky mucous builds up and produces a gagging cough. The incubation period of whooping cough is 7 to 10 days. Infected children are contagious from onset up to 21 days after the coughing has begun. Whooping cough was once known as the “hundred day cough” because that was the period from the onset to full recovery. This cough is more likely to occur in the spring or summer. It usually starts with a low grade fever, sneezing, a runny nose, and a loose cough which is worse at night. This may continue up to two weeks. They may also be achy with low energy, a loss of appetite, watery eyes, and earaches. Then the mucous becomes thick and the child cannot cough it up. The coughing fits often end in gagging and vomiting. The coughing can last from 8-10 coughs per breath. The child’s face can become blue, due to the long coughing bouts and shortness of breath. There can be a look of terror on the child’s face because the severity of the cough, being unable to catch their breath, or the pain of coughing which causes fear and dread. This stage can last up to six weeks. Do not attempt to treat whooping cough in a child under one year old.  Seek professional help.  Whooping cough requires patient observation and calmness; it is a long and tiring condition for child and parent. Remedy pictures can change, unexpectedly, and it is best to have expert help if the coughing persists. It is really advisable to have help from a homeopath for this condition and/or staying in close contact with your health care provider to provide your child with the utmost comfort.  It is rare for complications to occur in a child over one year old. However, it is important to monitor progress very carefully because the cough can become violent and damage the lungs. It can also cause a hernia in the navel or a bowel prolapse in the very young. Complications can include pneumothorax (collapsed lung) which needs emergency hospital treatment, pleurisy, or pneumonia. If the child persistently cries after coughing or a sudden high fever develops then you must seek professional help, immediately.  Again, this is rare. But one needs to by observant and use good judgement.

There are many remedies for whooping cough and it is not unusual for the child to need more than two of them. The most usual ones are: Antimonium Tart., Bryonia, Carbo Veg., Coccus Cacti, Cuprum Metallicum, Drosera, Ipecac, Lycopodium, Nux Vomica, Phosphorus and Spongia Tosta.

OBSERVING DIFFERENT KINDS OF COUGHS:

  • A dry cough is usually hacking and tickling, because the mucous membranes are dry or the mucous is tough and sticking to the air passages. The chest is usually tight. The remedies are:  Aconitum, Arsenicum, Belladonna, Bryonia, Causticum, Chamomilla, Ignatia, Iodium, Kali Bich, Lachesis, Nux Vomica, Phosphorus, Pulsatilla, Rumex, Spongea Tosta, and Sticta Pulmonaria.
  • A moist cough has a lot of mucous in the air passages. There is a loose rattling and bubbling sound in the chest. This can be heard in the cough or the breathing. Even though there is a lot of mucous, in some coughs, it is hard for the child to cough it up. These coughs can take awhile to clear and stop sounding so awful. The remedies are:  Antimonium Tart, Hepar Sulph, Ipecacuanha, Kali Sulph, Lycopodium, and Pulsatilla. 
  • Spasmodic coughs come in fits of uncontrollable, violent and prolonged coughing. The remedies are:  Carbo Veg, Coccus Cacti, Cuprum Metallicum, Drosera, Ignatia, and Ipecacuanha.

LISTENING TO THE SOUND OF A COUGH:

  • Machine gun cough – repeats frequently; can’t catch breath. Drosera, Coccus Cacti.
  • Rapid coughing spells. Rumex.
  • Barking, like a seal. Aconitum, Hepar Sulph.
  • Like a saw being driven through a pine board. Spongia Tosta.
  • Hissing with hoarseness. Antimonium Tart.
  • Rattling. Antimonium Tart, Coccus Cacti.

 WHAT TO OBSERVE:  Based on the above explanations, what kind of cough does the child have?  What is the sound of the cough: rattling, deep, hoarse, ringing, hacking, like a machine gun (in rapid succession), hollow or barking? Is the cough worse or better: talking; movement; sitting up or lying down; day or night; cool or warm air; dry or moist air; hot or cold drinks; inside or outside? What is the sound of the child’s breathing: wheezy, labored, or squeaky? If the child coughs up mucous does it have a specific taste: metallic, sweet, or salty? Is the child taking short shallow breaths? What color is the mucous, if they can cough it up? Is the mucous lumpy, frothy or stringy? Do they have a sore throat? Is there a tickling in the throat? What is the child’s mood? Does the child want warm or cold drinks or food, or want no food or drink? Is the child experiencing a fever or a headache? Take their temperature.

SUPPORTIVE MEASURES:  For All Coughs: Get extra rest. Push fluids, even if they only take a few sips at a time. This will help to keep the mucous loose. Do not force the child to eat, if they are not hungry. This gives the digestive system a rest and encourages the body to eliminate toxic wastes. If the child asks for food give a light diet, low in sugar, high in Vitamin C, and avoid stimulants such as cola or tea. Even if the chest is sore, encourage the child to cough. This will help to get the mucous out.  Use a vaporizer (cool or hot) depending on the type of cough. If you don’t have a vaporizer for a steam treatment, run the shower or tub spout with hot water in a closed bathroom. Have the child breathe in slow comfortably deep breaths.  Keep the temperature even. If you take the child outdoors, make sure they are bundled up well. Do not repress a cough with any form of cough medicine. To do so is blocking the body’s natural immune system of expelling mucous, which will prevent a deeper infection. Cough medicines make the child feel better temporarily because most of them contain about 25% alcohol. In some coughs, it is helpful for the child to be propped up with pillows in a semi-erect position. Always look in the “WORSE OR BETTER FROM” section for tips on what will make the child feel more comfortable, i.e. if a cough is worse lying on the back, encourage the child to lie on their side. For tickling coughs in children over three years old, you can use lozenges which do not contain: camphor, menthol, or eucalyptus, i.e. Blackcurrant pastilles or lemon drops. Discontinue or keep dairy products to a minimum, as this causes excess mucous. Humidify the room if you have forced air heat. Do not use any rubs or oils containing eucalyptus, menthol, camphor, tea tree oil. (These can nullify the homeopathic remedies).

Homemade cough treatments:

  • Lemon, honey and glycerine are soothing with tickling, teasing coughs. Squeeze half a lemon into a ½ cup of warm (not boiling) water; add a teaspoon of honey and two teaspoons of glycerine (pharmaceutical grade from the pharmacy). Give teaspoon doses as needed.
  • Thyme is traditionally used for coughs and lung problems. Make a ‘tea’ by pouring ½ pint of boiling water over a teaspoonful of leaves and flower tops (if you have them) and brew for 10 – 15 minutes. One old recipe calls for a pinch of rosemary, as well. Strain off the leaves and add honey to taste.
  • For a moist cough drink ginger tea. Boil three to four slices of fresh ginger in two cups of water and simmer for fifteen minutes.  Liquorice root tea is also good for moist coughs.

CALL YOUR HEALTH CARE PRACTITIONER IF:

  • Pains in the chest become persistent especially if they are present when not coughing.
  • Sharp pains shoot through the chest area if moving around.
  • Coughing produces blood streaked mucus.
  • A fever develops especially with alternating chills and heat with intermittent sweats.
  • Wheezing and rattling in the chest causes difficult breathing.
  • Hyperventilation (rapid breathing) or sleep apnoea (breathing stops for long periods during sleep).
  • The face goes blue with the effort of coughing or breathing.
  • Nausea and vomiting accompany gagging with the cough.
  • Loss of appetite over a period of several days.
  • Your child is becoming excessively fatigued or is not sleeping because of the coughing.
  • A cough lasts more than 3 days in an infant or 8 days in an older child.  The cough is severe, the child  can’t sleep because of it and no remedies have helped within 48 hours. 
  • If your child has a chronic cough or a cough that does not originate from a cold or flu. Chronic coughs can be from: allergies, asthma, liver problems, accidents which may have caused structural problems affecting the lungs, passive or active smoking (in teenagers) or a long unexpressed emotional reason (most usually grief). There is not always a cough present in children with pneumonia. Go to the hospital if your child has a fever; is breathing rapidly, erratically or with difficulty; is limp, lethargic and very pale.
  • There is a high fever; rapid swelling in the larynx; or excessive drooling on the pillow, because they cannot swallow. This points to a condition called Epiglottis, affecting 2 – 6 year olds, but is rare. It can be fatal if the airway becomes too swollen and closes off. Swelling initially causes a croupy sounding cough, but swelling with epiglottis rapidly closes the airway. There will be a raspy noisy sound on inspiration of the breath. IF YOU SUSPECT THIS CONDITION TAKE YOUR CHILD TO THE EMERGENCY ROOM IMMEDIATELY.
  • Article originally posted by http://hchild.com/tag/coughs/

Homeopathy Works - for your pets.

Homoeopathy Works;

It is amazing to me the amount of confusion surrounding homeopathy these days.  Amongst it all, one thing to me is always clear - it works.  Each and every party/social gathering that I go to where I encounter new people and of course they ask what it is that I do - I gather stories.

Last weekend at a wonderful Holiday Season gathering this happened with two lovely hippy-like dykes who enthusiastically recounted the story of seeing a homeopath for their dog. Their lovely dog had a list of complicated dire health needs. They had been going from vet to vet trying to get solutions and spending thousands and thousands of dollars with no results. They gleefully explained about the homeopath who was humbly going to 'give it a try'... to help their canine family member.

It was amazing to them that a $19 vial of homeopathic remedy could do wonders for their little fur baby. Homeopathy helps their dog recover in ways that no other medicine had done. They were so shocked in the contrast of spending over $26,000 on their dog, that the solution was in this very refined homeopathic medicine chosen by an experienced homeopathic practitioner. Homeopathy works wonders.

https://homeopathysquamish.wordpress.com/twyla-brooks-dch-animal-homeopath/