Homeopathy for shrimp aquaculture: increased survival and superoxide dismutase activity in juvenile white shrimp Litopenaeus vannamei during a bacterial pathogen-challenge.

Homeopathy for shrimp aquaculture: increased survival and superoxide dismutase activity in juvenile white shrimp Litopenaeus vannamei during a bacterial pathogen-challenge.

Authors:

Mazón-Suástegui, José ManuelBernal, Milagro GarcíaAbasolo-Pacheco, FernandoAvilés-Quevedo, AraceliCampa-Córdova, Ángel I.Rodríguez-Jaramillo, CarmenMarrero, Ricardo Medina

Affiliation:

Centro de Investigaciones Biológicas del Noroeste (CIBNOR, S.C.), México

Source:

Homeopathy (HOMEOPATHY), Feb2016; 105(1): 33-33. (1p)

Publication Type:

Article - abstract

Language:

English

Minor Subjects:

Homeopathic Agents -- Therapeutic UseAgricultureFish -- ClassificationImmunitySuperoxide Dismutase

Journal Subset:

Alternative/Complementary Therapies; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland

ISSN:

1475-4916

MEDLINE Info:

NLM UID: 101140517

Entry Date:

20160331

Revision Date:

20160331

DOI:

http://dx.doi.org/10.1016/j.homp.2015.12.057 

Accession Number:

112678428

Database:

CINAHL Complete

Systemic Contact Dermatitis from Herbal and Homeopathic Preparations Used for Herpes Virus Treatment.

Systemic Contact Dermatitis from Herbal and Homeopathic Preparations Used for Herpes Virus Treatment.

Abstract:

Systemic contact dermatitis may occur in contact-sensitized individuals when they are exposed to haptens orally, transcutaneously, intravenously or by inhalation. We report the case of a woman developing a diffuse skin eruption after the topical use of Rhus toxicodendron alcoholic extract and the oral introduction of a homeopathic preparation of the same substance for herpes treatment. An open test, performed with the Rhus toxicodendron tincture, showed an erythemato-oedematous response at 48 h and vesicular reaction at 96 h that was still present after 7 days. Patch test with 65% ethyl alcohol gave negative results. The open test performed, as control, in eight healthy informed subjects revealed negative responses to Rhus tincture application. The result is interesting because in Italy, allergic contact dermatitis to Rhus is uncommon and this case increases the understanding of the pathogenetic mechanism leading to systemic contact dermatitis development. [ABSTRACT FROM AUTHOR]

Authors:

Cardinali, Carla1
Francalanci, Stefano1,2
Giomi, Barbara1
Caproni, Marzia1
Sertoli, Achille2
Fabbri, Paolo1 Fabbri@unifi.it

Source:

Acta Dermato-Venereologica. May2004, Vol. 84 Issue 3, p223-226. 4p.

Document Type:

Report

Subject Terms:

*SKIN inflammation
*HAPTENS
*ANTIGENS
*HERPESVIRUS diseases
*IMMUNITY
*CARCINOGENESIS

Author-Supplied Keywords:

herpes virus infection
herpes virus infection.
homeopathy
mother tincture
plant extracts
Rhus toxicodendron

NAICS/Industry Codes:

325410 Pharmaceutical and medicine manufacturing
325414 Biological Product (except Diagnostic) Manufacturing

Copyright of Acta Dermato-Venereologica is the property of Society for Publication of Acta Dermato-Venereologica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Author Affiliations:

1II Dermatological Clinic, Department of Dermatological Sciences, University of Florence, Italy
2U.O. Allergological Unit, Department of Dermatological Sciences, University of Florence, Italy

ISSN:

0001-5555

DOI:

10.1080/00015550410023293

Accession Number:

12946175

Fifteen Years' Experience with HomeopathicImmunizations (Homeoprophylaxis)

Fifteen Years' Experience with HomeopathicImmunizations (Homeoprophylaxis)

Authors:

Hiltner, Richard

Affiliation:

Board of Directors, California Homeopathic Medical Society; Secretary, LIGA Letter, International HomeopathicMedical League

Source:

American Journal of Homeopathic Medicine (AM J HOMEOPATH MED), Summer2014; 107(2): 60-63. (4p)

Publication Type:

Journal Article - tables/charts

Language:

English

Major Subjects:

Homeopathy -- In Infancy and Childhood 
Immunization -- In Infancy and Childhood 
Nosode -- Therapeutic Use -- In Infancy and Childhood 
Communicable Diseases -- Prevention and Control -- In Infancy and Childhood

Minor Subjects:

Immunization ScheduleInfantChild, PreschoolChildHomeopathsDiphtheria-Tetanus-Pertussis Vaccine -- Adverse EffectsMeasles-Mumps-Rubella Vaccine -- Adverse EffectsIntellectual Disability -- Chemically InducedAutistic Disorder -- Chemically InducedSmallpox -- Prevention and ControlDiphtheria -- Prevention and ControlPoliomyelitis -- Prevention and Control

Abstract:

Over a fifteen-year period, 184 children between ages two months and twelve years were given potentized Polio, trivalent Diphtheria, Pertussis and Tetanus [DPT], and Measles, Mumps and Rubella [MMR] vaccines. None of the children developed those diseases over the course of the study. There was one episode of a minor skin eruption. If one adds this information to the results of the study by Isaac Golden on 1305 children over thirteen years, almost 1,500 children receiving homeopathic immunization obtained excellent results.

Journal Subset:

Alternative/Complementary Therapies; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA

Special Interest:

Pediatric Care

ISSN:

1934-2454

MEDLINE Info:

NLM UID: 101146804

Entry Date:

20140806

Revision Date:

20150712

Accession Number:

107870771

Database:

CINAHL Complete

Homeopathy and Antimicrobial Resistance...HRI Malta 2017¿Cutting Edge Research in Homeopathy: Presentation Abstracts

Homeopathy and Antimicrobial Resistance...HRI Malta 2017¿Cutting Edge Research in Homeopathy: Presentation Abstracts

Authors:

Fisher, Peter

Affiliation:

Royal London Hospital for Integrated Medicine, London, United Kingdom

Source:

Homeopathy (HOMEOPATHY), 2018 Supplement; 107: 55-78. (24p)

Publication Type:

Article - abstract, proceedings

Language:

English

Minor Subjects:

Homeopathic AgentsDrug Resistance, Microbial

Abstract:

Background: Antimicrobial resistance (AMR) is a massive global problem. An estimated 10 million people die annually from antibiotic resistant infections. The costs are projected to rise to $100 trillion a year by 2050. Dr Margaret Chan, Director-General of the World Health Organization (WHO) has said 'We are approaching a time when things as common as a strep throat or a child's scratched knee could once again kill'. The WHO takes AMR very seriously and has published data on AMR worldwide. Methods : I will review current strategies for tackling AMR. The Independent Review on AMR published in May 2016 made several recommendations. These include a global public awareness campaign, improved surveillance and more rapid diagnostic methods. The British Government has also published a strategy to tackle AMR. These recommendations will only slow, not reverse the spread of antibiotic resistance, unless new antibiotics are discovered. It is several decades since a new class of antibiotics was discovered. Neither of these strategies recommend exploration of innovative integrated medicine approaches. Results: I will present a head-to-head randomised clinical trial of an Echinacea preparation against oseltamivir, which has lessons for homeopathy research. I will discuss randomised controlled trials of homeopathy for infectious respiratory tract conditions and a health technology assessment of homeopathy. I will review the evidence from clinical effectiveness studies of homeopathy in this domain, including the large-scale French EPI-3 study and the two multinational IIPCOS studies. These consistently indicate that use of homeopathy is associated with much reduced use of antibiotics. Conclusion: Homeopathy should be part of an integrated strategy for tackling AMR. The homeopathic approach is not about killing micro-organisms; it seeks to promote patient resistance to infection, modulate innate immunity, and cultivate a healthy microbiome.

Journal Subset:

Alternative/Complementary Therapies; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland

ISSN:

1475-4916

MEDLINE Info:

NLM UID: 101140517

Entry Date:

20180215

Revision Date:

20180215

DOI:

http://dx.doi.org/10.1055/s-0038-1632420 

Accession Number:

127874169

Database:

CINAHL Complete

Effects of homeopathic arsenic on tobacco plant resistance to tobacco mosaic virus. Theoretical suggestions about system variability, based on a large experimental data set.

Effects of homeopathic arsenic on tobacco plant resistance to tobacco mosaic virus. Theoretical suggestions about system variability, based on a large experimental data set.

Abstract:

Context: This research aimed at verifying the efficacy of homeopathic treatments by plant-based bioassays, which may be suitable for basic research, because they lack placebo effects and provide large datasets for statistical analyses.
Objective: To evaluate the effects of homeopathic treatments of arsenic trioxide (As2O3) on tobacco plants subjected to tobacco mosaic virus (TMV) inoculation as biotic stress.
Design: Blind, randomized experiment using tobacco leaf disks.
Materials and Methods: Tobacco plants (Nicotiana tabacum L. cultivar Samsun) carrying the TMV resistance gene N. TMV inoculated leaf disks were floated for 3 days in the following: Distilled water (control). H2O 5 and 45 decimal and centesimal potencies. As2O3 5 and 45 decimal and centesimal potencies. The main outcome measures is the number of hypersensitive lesions observed in a leaf disk.
Results: Homeopathic treatments of arsenic induce two effects on the plant: (i) increased resistance to TMV; (ii) decrease variability between experiments (system variability).
Conclusions: In this experimental model two actions of homeopathic treatment were detected: decrease in system variability and enhancement of the natural tendency of the system towards an 'equilibrium point'.

Authors:

Betti L; Department of Agro-Environmental Science and Technology, Faculty of Agriculture, Bologna University, Italy. lucietta.betti@unibo.it
Lazzarato L
Trebbi G
Brizzi M
Calzoni GL
Borghini F
Nani D

Source:

Homeopathy: The Journal Of The Faculty Of Homeopathy [Homeopathy] 2003 Oct; Vol. 92 (4), pp. 195-202.

Publication Type:

Journal Article; Research Support, Non-U.S. Gov't

Language:

English

Journal Info:

Publisher: Elsevier Science Country of Publication: Germany NLM ID: 101140517 Publication Model: Print Cited Medium: Print ISSN: 1475-4916 (Print) Linking ISSN: 14754916 NLM ISO Abbreviation: Homeopathy Subsets: MEDLINE

Imprint Name(s):

Original Publication: Edinburgh : Elsevier Science, c2002-

MeSH Terms:

Immunity, Innate*
Antiviral Agents/*pharmacology 
Arsenicals/*pharmacology 
Oxides/*pharmacology 
Plant Diseases/*virology 
Plant Leaves/*immunology 
Tobacco/*virology 
Tobacco Mosaic Virus/*immunology
Biological Assay ; Homeopathy/methods ; Plant Leaves/virology ; Research Design ; Time Factors ; Tobacco Mosaic Virus/metabolism

Substance Nomenclature:

0 (Antiviral Agents)
0 (Arsenicals)
0 (Oxides)
S7V92P67HO (arsenic trioxide)

Entry Date(s):

Date Created: 20031101 Date Completed: 20040305 Latest Revision: 20180305

Update Code:

20180306

PMID:

14587686

Database:

MEDLINE with Full Text

The immunomodulatory effects of a commercial antiviral homeopathic compound in C57BL/6 mice, pre and post vaccine challenge.

The immunomodulatory effects of a commercial antiviral homeopathic compound in C57BL/6 mice, pre and post vaccine challenge.

Abstract:

Homeopathic remedies have been selectively employed in human medicine since Hahneman introduced the concept in 1828. While the use of homeopathy is regionally popular in both human and veterinary medicine, there is still a significant lack of scientific evidence supporting its efficacy. This is likely due to an absence of studies evaluating the mechanism of action of these compounds. Engystol® an FDA-approved antiviral agent, is a popular homeopathic commercial product. In select in vivo and in vitro observational studies, the drug showed a measureable innate immune therapeutic efficacy. The focus of the present study was to evaluate the innate and adaptive immunomodulatory effects of oral Engystol ® (1 or 10 tablets/L water consumed), prior to and post antigenic challenge in a mouse model with a well-characterized and clinically measureable immune system. We first evaluated the murine immune response when oral Engystol ® was given alone for 28 days. Mice were then challenged with an antigen-specific H5N1 HA vaccine while on Engystol ® for an additional 33 days. Serum and supernatants from cultured splenic lymphocytes were collected and screened with a 32-cytokine panel. Serum vaccine epitope-specific IgG titers plus T cell and B cell phenotypes from splenic tissue were also evaluated. Preliminary results showed that Engystol ® alone did not alter immunity; however, upon vaccine challenge, Engystol ® decreased CD4 + /CD8 + ratios, altered select cytokines/chemokines, and anti-H5N1 HA IgG titers were increased in the 10 tablet/L group. Collectively, these data suggest that Engystol ® can modulate immunity upon antigenic challenge. [ABSTRACT FROM AUTHOR]

Authors:

Mayer, Jörg1
Williams, Robert J.2
Oppenheimer, Victor A.2
He, Biao3
Tuckfield, Cary4
Koslowski, Eric5
Jr.Gogal, Robert M.2 rgogal@uga.edu

Source:

International Immunopharmacology. Oct2016, Vol. 39, p389-396. 8p.

Document Type:

Article

Subject Terms:

*HOMEOPATHIC materia medica & therapeutics
*ANTIVIRAL agents
*ANIMAL models of immunology
*BIOLOGICAL response modifiers
*IMMUNOGLOBULIN G
*IMMUNOREGULATION
*DRUG efficacy

Author-Supplied Keywords:

C57BL/6
Cytokine
Engystol ®
IgG
Lymphocyte
Mouse

NAICS/Industry Codes:

325410 Pharmaceutical and medicine manufacturing

Copyright of International Immunopharmacology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Author Affiliations:

1Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, 501 DW Brooks Drive, Athens, GA 30602, USA
2Department of Biosciences and Diagnostic Imaging, College of Veterinary Medicine, University of Georgia, 501 DW Brooks Drive, Athens, GA 30602, USA
3Department of Infectious Disease, College of Veterinary Medicine, University of Georgia, 501 DW Brooks Drive, Athens, GA 30602, USA
4ECOSTATys LLC, 105 Highland Forest Dr. Aiken, SC 29803, USA
5ETR-Labs, Leominster, MA 01453-4864, USA

ISSN:

1567-5769

DOI:

10.1016/j.intimp.2016.08.003

Accession Number:

117837593

Systemic Contact Dermatitis from Herbal and Homeopathic Preparations Used for Herpes Virus Treatment.

Systemic Contact Dermatitis from Herbal and Homeopathic Preparations Used for Herpes Virus Treatment.

Abstract:

Systemic contact dermatitis may occur in contact-sensitized individuals when they are exposed to haptens orally, transcutaneously, intravenously or by inhalation. We report the case of a woman developing a diffuse skin eruption after the topical use of Rhus toxicodendron alcoholic extract and the oral introduction of a homeopathic preparation of the same substance for herpes treatment. An open test, performed with the Rhus toxicodendron tincture, showed an erythemato-oedematous response at 48 h and vesicular reaction at 96 h that was still present after 7 days. Patch test with 65% ethyl alcohol gave negative results. The open test performed, as control, in eight healthy informed subjects revealed negative responses to Rhus tincture application. The result is interesting because in Italy, allergic contact dermatitis to Rhus is uncommon and this case increases the understanding of the pathogenetic mechanism leading to systemic contact dermatitis development. [ABSTRACT FROM AUTHOR]

Copyright of Acta Dermato-Venereologica is the property of Society for Publication of Acta Dermato-Venereologica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Authors:

Cardinali, Carla1
Francalanci, Stefano1,2
Giomi, Barbara1
Caproni, Marzia1
Sertoli, Achille2
Fabbri, Paolo1 Fabbri@unifi.it

Source:

Acta Dermato-Venereologica. May2004, Vol. 84 Issue 3, p223-226. 4p.

Document Type:

Report

Subject Terms:

*SKIN inflammation
*HAPTENS
*ANTIGENS
*HERPESVIRUS diseases
*IMMUNITY
*CARCINOGENESIS

Author-Supplied Keywords:

herpes virus infection
herpes virus infection.
homeopathy
mother tincture
plant extracts
Rhus toxicodendron

NAICS/Industry Codes:

325410 Pharmaceutical and medicine manufacturing
325414 Biological Product (except Diagnostic) Manufacturing

Author Affiliations:

1II Dermatological Clinic, Department of Dermatological Sciences, University of Florence, Italy
2U.O. Allergological Unit, Department of Dermatological Sciences, University of Florence, Italy

ISSN:

0001-5555

DOI:

10.1080/00015550410023293

Accession Number:

12946175

Homeopathic treatment as an alternative prophylactic to minimize bacterial infection and prevent neonatal diarrhea in calves.

Homeopathic treatment as an alternative prophylactic to minimize bacterial infection and prevent neonatal diarrhea in calves.

Abstract:

Bovine neonatal diarrhea is common due low immunity in newborn calves, poor management (or absence) of sanitary barriers, and other factors. Newborn calves with diarrhea in the first days of life suffer failure to thrive and may die if left untreated. The aim of this study was to evaluate whether prophylactic administration of a homeopathic product (Dia 100 ® ) can control bovine neonatal diarrhea in calves born on a farm with substantial sanitary challenges. We counted total bacteria and protozoan parasites in fecal samples. We measured serum glucose, total protein, globulin, albumin, cholesterol and triglycerides on days 1, 7 and 14 of life. Twenty newborn calves were maintained in individual stalls, and were divided in two groups: ten untreated animals (control) and ten animals treated with Dia 100 ® . Fecal consistency was evaluated daily. We diagnosed diarrhea in five animals in the treated group, and in all animals from the control group. Infections with Escherichia coli and Giardia duodenalis were identified as the responsible organisms. The E. coli count was low in the treatment group on day 7 of life compared with the control group. Antibiotics were given to eight animals in the control group, and to two animals in the treatment group. On day of life 7, serum levels of total protein and globulins were higher in the control group, but were lower on day 14. Serum levels of glucose and triglycerides were greater in treated animals on days 7 and 14, suggesting that the homeopathic product contributes to improvement of intestinal health and absorption and nutrients. We conclude that Dia 100 ® controls diarrhea with 50% of efficacy, and reduces antibiotic utilization. [ABSTRACT FROM AUTHOR]

Copyright of Microbial Pathogenesis is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Authors:

Fortuoso, Bruno F.1
Volpato, Andreia2
Rampazzo, Luana1
Glombowsky, Patrícia1
Griss, Luiz Gustavo1
Galli, Gabriela M.1
Stefani, Lenita M.1,2
Baldissera, Matheus D.3
Ferreira, Emanuel B.4
Machado, Gustavo5
da Silva, Aleksandro S.1,2 aleksandro_ss@yahoo.com.br

Source:

Microbial Pathogenesis. Jan2018, Vol. 114, p95-98. 4p.

Document Type:

Article

Subject Terms:

*HOMEOPATHY
*NEONATAL diarrhea in cattle
*BACTERIAL diseases in animals
*PREVENTION
*MICROBIOLOGY
*FECES
*GIARDIA

Author-Supplied Keywords:

Calves
Diarrhea
E. coli
Homeopathic
Intestinal health
Treatment

Author Affiliations:

1Department of Animal Science, Universidade do Estado de Santa Catarina (UDESC), Brazil
2Post-Graduate Program in Animal Science, Universidade do Estado de Santa Catarina (UDESC), Brazil
3Department of Microbiology and Parasitology, Universidade Federal de Santa Maria (UFSM), Brazil
4Medical Veterinarian, Londrina, Brazil
5Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, USA

ISSN:

0882-4010

DOI:

10.1016/j.micpath.2017.11.041

Accession Number:

128003381

You give me fever.

You give me fever.

Authors:

Johnson, Paul

Source:

TES: Times Educational Supplement. 10/12/2001, Issue 4450, TES FRIDAY p14. 2p. 1 Black and White Photograph.

ABSTRACT: Discusses guidelines in preventing an influenza epidemic in schools in Great Britain. Immunization of children; Medication with the anti-viral drug Relenza 48 hours after contracting the disease; Frequent handwashing; Regular cleaning classrooms with disinfectant; Advising students to cover the nose and mouth when sneezing; Increasing intake of vitamin C- and zinc-rich food.

Supplement use, other dietary and demographic variables and serum vitamin C in NHANES II.

Supplement use, other dietary and demographic variables and serum vitamin C in NHANES II.

Authors:

Dickinson, V.A.
Block, G.

Source:

Journal of the American Dietetic Association. Jul94, Vol. 94 Issue 7, p792. 1/8p.

Document Type:

Article

Subject Terms:

*DIETARY supplements
*SEROTHERAPY

NAICS/Industry Codes:

446191 Food (Health) Supplement Stores
414510 Pharmaceuticals and pharmacy supplies merchant wholesalers

Abstract:

Reports on the result of a study about the effects of the use of regular supplement to serum vitamin C levels.

Genetically Engineered Ascorbic acid-deficient Live Mutants of Leishmania donovani induce long lasting Protective Immunity against Visceral Leishmaniasis.

Anand, S., & Madhubala, R. (2015). Genetically Engineered Ascorbic acid-deficient Live Mutants of Leishmania donovani induce long lasting Protective Immunity against Visceral Leishmaniasis. Scientific Reports, 10706. https://doi.org/10.1038/srep10706

ABSTRACT:Visceral leishmaniasis caused by Leishmania donovani is the most severe systemic form of the disease. There are still no vaccines available for humans and there are limitations associated with the current therapeutic regimens for leishmaniasis. Recently, we reported functional importance of Arabino-1, 4-lactone oxidase (ALO) enzyme from L. donovani involved in ascorbate biosynthesis pathway. In this study, we have shown that ΔALO parasites do not affect the ability of null mutants to invade visceral organs but severely impair parasite persistence beyond 16 week in BALB/c mice and hence are safe as an immunogen. Both short term (5 week) and long term (20 week) immunization with ΔALO parasites conferred sustained protection against virulent challenge in BALB/c mice, activated splenocytes and resulted in induction of pro-inflammatory cytokine response. Protection in immunized mice after challenge correlated with the stimulation of IFN-γ producing CD4+ and CD8+ T cells. Antigen-mediated cell immunity correlated with robust nitrite and superoxide generation, macrophage-derived oxidants critical in controlling Leishmania infection. Our data shows that live attenuated ΔALO parasites are safe, induce protective immunity and can provide sustained protection against Leishmania donovani. We further conclude that the parasites attenuated in their anti-oxidative defence mechanism can be exploited as vaccine candidates.

Addition of ascorbic acid solution to stored murine red blood cells increases posttransfusion recovery and decreases microparticles and alloimmunization.

Stowell, S. R., Smith, N. H., Zimring, J. C., Fu, X., Palmer, A. F., Fontes, J., … Yazer, M. H. (2013). Addition of ascorbic acid solution to stored murine red blood cells increases posttransfusion recovery and decreases microparticles and alloimmunization. Transfusion, 53(10), 2248–2257. https://doi.org/10.1111/trf.12106

ABSTRACT: Background The storage of red blood cells ( RBCs) results in numerous changes, which over time result in decreased recovery of transfused RBCs. In addition (at least in animal models), stored RBCs can be more immunogenic and also stimulate the systemic release of inflammatory cytokines in transfusion recipients. One component of the RBC storage lesion is the accumulation of oxidative damage. We tested the hypothesis that adding a chemical antioxidant (ascorbic acid) to stored RBCs would improve the quality of the stored RBCs. Study Design and Methods RBCs were harvested from FVB. HOD mice that express an RBC-specific model transgene ( HOD) and stored for 14 days with either ascorbic acid in saline or saline alone. Twenty-four-hour posttransfusion recovery of RBCs was tracked by flow cytometry. Alloimmunization was monitored by flow cytometry crossmatch. Cytokines were monitored by multiplex bead arrays. Results RBCs stored under standard conditions had decreased 24-hour posttransfusion recovery and increased induction of both alloantibodies and interleukin ( IL)-6 and monocyte chemoattractant protein ( MCP)-1 secretion in the mouse recipients. Addition of ascorbic acid from 3.6 to 10.8 mmol/ L resulted in a significant decrease in microparticle formation, an improved RBC 24-hour posttransfusion recovery (p < 0.01), and a decrease in recipient alloimmunization (p = 0.0001). Induction of MCP-1 and IL-6 secretion was not decreased by ascorbic acid. Conclusions These data indicate that the addition of ascorbic acid solution to RBCs during storage has a beneficial effect on recovery and immunogenicity of RBCs, but not cytokine induction. The addition of ascorbic acid (or other antioxidants) to human RBCs may have beneficial effects. [ABSTRACT FROM AUTHOR]

Vitamin C supplementation improved the efficacy of foot-and-mouth disease vaccine.

Vitamin C supplementation improved the efficacy of foot-and-mouth disease vaccine. By: Wu, Minsheng, He, Meina, Kang, Youmin, Food & Agricultural Immunology, 09540105, Dec2018, Vol. 29, Issue 1

Database: Academic Search Complete

Vitamin C supplementation improved the efficacy of foot-and-mouth disease vaccine 

Vitamin C (VC) is an essential micronutrient and plays important roles in various biological processes including immune responses. Vaccination can stimulate immune responses effectively for prevention of virual infection. Adequate VC intake is required for the immune system to function efficiently. In this study, we evaluated the biological function of VC on immune response to inactivated foot-and-mouth disease (FMD) vaccine. The C57BL/6 mice were injected intraperitoneally with different dose of VC daily following immunization with inactivated FMD vaccine. The results showed high dose of VC supplementation significantly increased IgG level. Similarly, high dose of VC supplementation enhanced Th2 and Th17 cellular immune responses and also increased MHCII expression on dendritic cells. Taken together, these data indicate that high dose of VC supplementation can modulate Th2 and Th17 cellular immune responses to inactivated FMD vaccine and manifest the necessity for effective vaccination.

Keywords: Vitamin C; foot-and-mouth disease; vaccine; efficacy

Steve Scrutton's Homeopathic Safe Medicine Post

Wednesday, 9 January 2019

Recent medical news indicating that conventional medicine is dangerous. So why is the public never told about any of it?

The history of conventional medicine is full of failures, horrors and patient disasters. In the 19th century it used techniques like blood letting and blistering, and drugs now recognised to be dangerous, like Laudanum, Calomel and Antimony. Many more pharmaceutical drugs followed during the 20th century, passing through Thalidomide, Fen-Phen, Baycol, Tysabri, Effexor, Avandia, Vioxx, and many, many more, listed on this link, but too numerous to mention here.

Past performance is always the best predictor of future performance.
So are today's drugs, the one's doctors are giving us now, any better? Regular readers of this blog will know that they are not. They are causing side effects, adverse reactions, that are generating the rapid increase of serious chronic illness and disease. Conventional medicine is well aware of this but in their pursuit of profit they are prepared to continue prescribing these dangerous drugs up to the point that doctors can no longer keep the truth from us.

The problem is that the harm being caused by pharmaceutical drugs and vaccines are never publicised. Our doctors, our national health services, our politicians and governments, and the mainstream media organisations, just don't bother to tell us.

So whilst we may be aware of some of the drugs and vaccines that have been banned and withdrawn in the past, few people are aware of the harm present day 'medications' are causing. To demonstrate this, I thought that I would bring together some of the recent news stories, since the recent holiday period, about the dangers that conventional medicine, and pharmaceutical drugs particularly, present to our health, THAT WE ARE JUST NOT TOLD ABOUT.

VACCINE CONTAMINANTS
This article states that there have been hundreds of articles in medical journals that have found stray viruses, aluminum, mercury, etc., in vaccines, and asks whether this happens in error, or is a regular occurrence. It refers to Italian and French researchers who looked at 44 vaccines, and found inorganic contaminants IN EVERY SINGLE ONE!

You will not find this reported anywhere in the mainstream media!
VACCINE BOMBSHELL This article states that a 'confidential' GlaxoSmithKline document, recently leaked to the press, showed that 36 infants had died in the last two years after having received the "6-in-1" vaccine, Infanrix Hexa.
Leaked to the press? Perhaps, but you will not find this reported in the mainstream media either!
MEDICAL SCIENCE DELIBERATELY HIDING HPV VACCINE DEATHS?
Drug manufacturers & regulators accused of concealing harm done to young girls by vaccine, including death permanent injury, and life threatening reactions

Reported just over a year ago, but hidden, dismissed and minimised by medical science - and, of course, censored by the mainstream media.
ANTIBIOTICS LINKED TO FATAL HEART CONDITION The Dr Mercola website has reported this month that Fluoroquinolone antibiotics, prescribed for upper respiratory and urinary tract infections, have been found to increase the risk of aortic dissection, which can lead to death. The article states that these antibiotics have long been associated with 'adverse events' that include psychiatric effects, kidney stones or failure, tendon rupture and retinal detachment leading to blindness.

If you think we might want to know about these dangerous side effects,  the mainstream media does not agree. They have never mentioned the new evidence.
These are just some of the articles I have come across since the holiday period. I could provide you with many more (check my Tweets (@stevescrutton), my Facebook page, or my Linkedin page, regularly for these. But the main point is that no-one should ever assume that the pharmaceutical drugs and vaccines that our doctors are giving us today are safe.

If we are not aware of the dangers of today's drugs it is because we are never told about them - until after hundreds, thousands, millions of patients have been seriously harmed by them!

https://safe-medicine.blogspot.com/2019/01/recent-medical-news-indicating-that.html