Effects of homeopathic arsenic on tobacco plant resistance to tobacco mosaic virus. Theoretical suggestions about system variability, based on a large experimental data set.

Effects of homeopathic arsenic on tobacco plant resistance to tobacco mosaic virus. Theoretical suggestions about system variability, based on a large experimental data set.


Context: This research aimed at verifying the efficacy of homeopathic treatments by plant-based bioassays, which may be suitable for basic research, because they lack placebo effects and provide large datasets for statistical analyses.
Objective: To evaluate the effects of homeopathic treatments of arsenic trioxide (As2O3) on tobacco plants subjected to tobacco mosaic virus (TMV) inoculation as biotic stress.
Design: Blind, randomized experiment using tobacco leaf disks.
Materials and Methods: Tobacco plants (Nicotiana tabacum L. cultivar Samsun) carrying the TMV resistance gene N. TMV inoculated leaf disks were floated for 3 days in the following: Distilled water (control). H2O 5 and 45 decimal and centesimal potencies. As2O3 5 and 45 decimal and centesimal potencies. The main outcome measures is the number of hypersensitive lesions observed in a leaf disk.
Results: Homeopathic treatments of arsenic induce two effects on the plant: (i) increased resistance to TMV; (ii) decrease variability between experiments (system variability).
Conclusions: In this experimental model two actions of homeopathic treatment were detected: decrease in system variability and enhancement of the natural tendency of the system towards an 'equilibrium point'.


Betti L; Department of Agro-Environmental Science and Technology, Faculty of Agriculture, Bologna University, Italy. lucietta.betti@unibo.it
Lazzarato L
Trebbi G
Brizzi M
Calzoni GL
Borghini F
Nani D


Homeopathy: The Journal Of The Faculty Of Homeopathy [Homeopathy] 2003 Oct; Vol. 92 (4), pp. 195-202.

Publication Type:

Journal Article; Research Support, Non-U.S. Gov't



Journal Info:

Publisher: Elsevier Science Country of Publication: Germany NLM ID: 101140517 Publication Model: Print Cited Medium: Print ISSN: 1475-4916 (Print) Linking ISSN: 14754916 NLM ISO Abbreviation: Homeopathy Subsets: MEDLINE

Imprint Name(s):

Original Publication: Edinburgh : Elsevier Science, c2002-

MeSH Terms:

Immunity, Innate*
Antiviral Agents/*pharmacology 
Plant Diseases/*virology 
Plant Leaves/*immunology 
Tobacco Mosaic Virus/*immunology
Biological Assay ; Homeopathy/methods ; Plant Leaves/virology ; Research Design ; Time Factors ; Tobacco Mosaic Virus/metabolism

Substance Nomenclature:

0 (Antiviral Agents)
0 (Arsenicals)
0 (Oxides)
S7V92P67HO (arsenic trioxide)

Entry Date(s):

Date Created: 20031101 Date Completed: 20040305 Latest Revision: 20180305

Update Code:





MEDLINE with Full Text

Strychnos nux-vomica extract and its ultra-high dilution reduce voluntary ethanol intake in rats.

homeopathy for addictions science

Read More

An integral approach to substance abuse.,Amodia DS, Cano C, Eliason MJ.

integral approach to substance abuse and addictions

Read More

Dr. Iris Bell M.D. Ph.D. does it again!

Research in Homeopathy:

If anyone is ever asking you to back up your interest in homeopathy with 'Evidence-based Research' or 'clinical proof' or RCT (Random Control Trials) scientific research, please help them by referring to this list or also by sharing this email. Here is a link that displays a pdf of a Reference List of 138 pages worth of Homeopathic Research. This list was curated by Dr. Iris Bell M.D. Ph. D. and Peter Gold in 2015. Much more research has been published since this collection almost two years ago. Hope this helps lead anyone to any type of research with regards to the use of homeopathy and homeopathic remedies. Anyone is welcome to download this pdf file and use it or pass it on. http://www.homeopathy.ca/pdf/HomeopathyResearchEvidenceBase_10-29-15.pdf

Extreme homeopathic dilutions retain starting materials: A nanoparticulate perspective.

Homeopathy. 2010 Oct;99(4):231-42.Extreme homeopathic dilutions retain starting materials: A nanoparticulate perspective.

Chikramane PS, Suresh AK, Bellare JR, Kane SG. Department of Chemical Engineering, Indian Institute of Technology, Bombay, Adi Shankaracharya Marg, Powai, Mumbai, Maharashtra, India.

Comment in:

Homeopathy. 2010 Oct;99(4):229-30. Abstract Homeopathy is controversial because medicines in high potencies such as 30c and 200c involve huge dilution factors (10⁶⁰ and 10⁴⁰⁰ respectively) which are many orders of magnitude greater than Avogadro's number, so that theoretically there should be no measurable remnants of the starting materials. No hypothesis which predicts the retention of properties of starting materials has been proposed nor has any physical entity been shown to exist in these high potency medicines. Using market samples of metal-derived medicines from reputable manufacturers, we have demonstrated for the first time by Transmission Electron Microscopy (TEM), electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES), the presence of physical entities in these extreme dilutions, in the form of nanoparticles of the starting metals and their aggregates.

Copyright © 2010 The Faculty of Homeopathy. Published by Elsevier Ltd. All rights reserved.

Read more: http://www.cbc.ca/consumer/story/2011/01/14/f-homeopathy-naturopathic-marketplace.html#socialcomments#ixzz1B8T9HgtE

Gelsemium sempervirens effects in vitro: A bridge between homeopathy and molecular biology?

Gelsemium sempervirens effects in vitro: A bridge between
homeopathy and molecular biology?
Debora Olioso, Marta Marzotto, Clara Bonafini, Paolo Bellavite
Department of Pathology and Diagnostics, University of Verona
Correspondence: debora.olioso@univr.it


MYTHs about Homeopathy - A Series of responses.

“There is no scientific evidence that homeopathy works”

This is probably the most frequently quoted, completely inaccurate statement about homeopathy. Homeopathy research is a relatively new field, so it’s true to say that there are not a huge number of studies, but some evidence is very different from no evidence.

By the end of 2013, 188 randomised controlled trials of homeopathy on 100 different medical conditions had been published in peer-reviewed journals1:

  • 44% were positive (82 trials) – finding that homeopathy was effective
  • 5% were negative (10 trials) – finding that homeopathy was ineffective
  • 47% were inconclusive (89 trials)

How does this compare with evidence for conventional medicine?


An analysis of 1016 systematic reviews of RCTs of conventional medicine had strikingly similar findings2:

  • 44% were positive – the treatments were likely to be beneficial
  • 7% were negative – the treatments were likely to be harmful
  • 49% were inconclusive – the evidence did not support either benefit or harm.

Although the percentages of positive, negative and inconclusive results are  similar in homeopathy and conventional medicine, it is important to recognise a vast difference in the quantity of research carried out; chart A represents 188 individual trials on homeopathy, whereas chart B represents 1016 reviews on conventional medicine, each analysing multiple trials.

This highlights the need for more research in homeopathy, particularly large-scale high quality repetitions of the most promising positive studies.

The difference in quantity is also not surprising when one considers the tiny amounts of funding made available for research into ‘complementary and alternative medicine’ (CAM).  For example, in the UK only 0.0085% of the total medical research 
budget is spent on CAM, of which homeopathy is only one example3.




Dr. Bhatia – Please share with us the most significant findings of your research?

Dr. Isaac – There is so much that could be said, but I would say that the three most significant findings are:

(1)   The consistency of measures of the effectiveness of HP over 200 years, both for long-term and short-term protection – at around 90%.  This is a very strong figure, and very consistent with vaccine efficacy. My own data was collected from 1986 to 2004, and vetted by a Professor of Medicine and a medical epidemiologist during my Swinburne research. So it means we can offer people a safe alternative with a demonstrated effectiveness.

(2)   Evaluation of the overall safety of long-term HP was an important new aspect of my Doctoral research at Swinburne University from 2000 to 2004, and the results were excellent. Some of my colleagues had quite reasonably questioned whether the use of my long-term program could cause any weakening of the Vital Force over time, and the data unambiguously said “no” to that question. It further showed that my long-term HP program was associated with an improvement in general well being– a result that pleased, but also surprised me to some extent.

(3)   How damaging vaccination is over the long-term. Once again, the results are unambiguous, and are fully consistent with the very few long-term studies of the impact of vaccination on overall wellness. The fact that the orthodox community has done so little genuine research into long-term safety of vaccination is to their eternal discredit.



Modulation of Signal Proteins: A PlausibleMechanism to Explain How a Potentized Drug Secale Cor 30C Diluted beyond Avogadro's Limit Combats Skin Papilloma in Mice

Hindawi Publishing Corporation | Evidence-Based Complementary and Alternative Medicine | Volume 2011, Article ID 286320, 12 pages

Modulation of Signal Proteins: A PlausibleMechanism to Explain How a Potentized Drug Secale Cor 30C Diluted beyond Avogadro's Limit Combats Skin Papilloma in Mice

Anisur Rahman Khuda-Bukhsh,1 Soumya Sundar Bhattacharyya,1 Saili Paul,1 Suman Dutta,1 Naoual Boujedaini,2 and Philippe Belon2

1Cytogenetics and Molecular Biology Laboratory, Department of Zoology, University of Kalyani, Kalyani 741235, West Bengal, India 2Boiron Laboratory, Lyon, France

Copyright © 2011 Anisur Rahman Khuda-Bukhsh et al. This is an open access article.

In homeopathy, ability of ultra-high diluted drugs at or above potency 12C (diluted beyond Avogadro's limit) in ameliorating/curing various diseases is often questioned, particularly because the mechanism of action is not precisely known. We tested the hypothesis if suitable modulations of signal proteins could be one of the possible pathways of action of a highly diluted homeopathic drug, Secale cornutum 30C (diluted 1060 times; Sec cor 30). It could successfully combat DMBA + croton oilinduced skin papilloma in mice as evidenced by histological, cytogenetical, immunofluorescence, ELISA and immunoblot findings. Critical analysis of several signal proteins like AhR, PCNA, Akt, Bcl-2, Bcl-xL, NF-κB and IL-6 and of pro-apoptotic proteins like cytochrome c, Bax, Bad, Apaf, caspase-3 and -9 revealed that Sec cor 30 suitably modulated their expression levels along with amelioration of skin papilloma. FACS data also suggested an increase of cell population at S and G2 phases and decrease in sub- G1 and G1 phages in carcinogen-treated drug-unfed mice, but these were found to be near normal in the Sec cor 30-fed mice. There was reduction in genotoxic and DNA damages in bone marrow cells of Sec Cor 30-fed mice, as revealed from cytogenetic and Comet assays. Changes in histological features of skin papilloma were noted. Immunofluorescence studies of AhR and PCNA also suggested reduced expression of these proteins in Sec cor 30-fed mice, thereby showing its anti-cancer potentials against skin papilloma. Furthermore, this study also supports the hypothesis that potentized homeopathic drugs act at gene regulatory level.